Essential Oils and Aromatherapy for Pain Relief

Posted by Zack Grasso on

What are safe and effective essential oils for pain relief?

Many essential oils have proven safe and effective at reducing pain, and two of the most studied essential oils for pain are lavender and orange. However, a number of other oils have also demonstrated efficacy, including peppermint, bergamot, and frankincense, and systematic reviews and meta-analyses have supported the efficacy of essential oils and aromatherapy for pain in general as well.

     Lavender and Orange

What are the active components of essential oils for pain relief?

The compounds in essential oils responsible for their ability to relieve pain and other symptoms are numerous, and many oils overlap greatly in which compounds they contain. The primary molecules responsible for the analgesic effects of lavender and orange essential oils are linalool and limonene, respectively (pictured below). Some of the other more common compounds with research supporting their pain-relieving properties are citronellal, carvacrol, eugenol, menthol, vanillin, carvone, p-cymene, and farsenol, to name a few, but the list goes on

What are terpenes?

You might have come across the word 'terpenes' recently, as it has become a bit of a buzzword due to the increased interest in recreational and medicinal cannabis use and cultivation. It was actually coined in 1866, however, and is a term that has long been familiar to chemists, aromatherapists, and perfumers, and it is used to describe all of the molecules mentioned above. 

The term terpenes technically refers to molecules with an empirical structure of C10H16, or two isoprene units (a very simple but fascinating and prolific molecule), like limonene pictured below. Now, however, the term is also used when talking about similar molecules containing additional functional groups, like the alcohol linalool, displayed alongside limonene for structural comparison. Linalool is technically a terpenoid alcohol, and its additional hydroxyl group is just one of many functional groups represented in this large of molecules, so 'terpenoid' is a more accurate and inclusive term. All these molecules are known as volatile organic compounds (VOCs), meaning that they evaporate readily, which is how we are able to smell them. 

Isoprene and IsoprenolLimonene vs Linalool


You may have also come across the words monoterpenesesquiterpene, or diterpene. These prefixes refer to the number of C10H16 units these molecules are structurally composed of. Limonene is considered a monoterpene and linalool a monoterpenoid, whereas Farnesol, which has 15 carbons, is considered a sesquiterpenoid, coming from the Latin sesqui- ("increase by 1/2"), from semi- ("half") and -que ("and; also"), having one and a half times as many carbons as a monoterpene. Once you start going beyond three isoprene units, however, the molecules start becoming larger and less volatile, making them less prone to evaporation and, therefore, less relevant to aromatherapy., 

There is nothing cannabis-specific about any of these compounds. If you look at the literature, in fact, they have been studied and documented relatively extensively since long before the recent craze over their presence in different cannabis strains and extracts.

How does aromatherapy for pain relief work?

Pain reduction is one of the less intuitive applications of clinical aromatherapy – How could just smelling something make us actually feel less pain?

Pain is a complex feeling, and our experience of it is shaped not just by its direct causes but by a myriad of other factors. There are many different kinds of pain in terms of how it manifests biochemically. Different essential oils contain different compounds, as explored briefly above, and when they enter the nasal cavity, they are recognized by different receptors. These receptors then immediately send a signal to the brain, and different neurochemical changes occur depending on the signal the brain receives. Many of these processes are involved in how our body signals to our brain that something is wrong or requires our attention, which we experience as pain. However, these processes can be altered via many mechanisms, one of which is aromatherapy.

Essential Oil Aromatherapy Mechanism of Action Biochemical Pathways

Aromatherapy is able to provide near-instantaneous pain relief because of the direct connection between our scent receptors and our brains, unlike treatments involving ingestion or venipuncture. Because our experience of pain is so multifaceted, the blending of multiple essential oils can help target a variety of contributing biochemical pathways, making it effective both on its own and in tandem with complementary treatments, depending on the type or severity of the pain.

Request Ascents Clinical Aromatherapy Samples

Why should essential oils be used for pain relief?

A recent Gallup poll found that:

​​"In 2021, four in 10 adults worldwide said they experienced a lot of worry (42%) or stress (41%), and slightly more than three in 10 experienced a lot of physical pain (31%). More than one in four experienced sadness (28%), and slightly fewer experienced anger (23%)." 

It’s relatively common knowledge that prescription pain medication use has been on the rise for some time now, and that the opioid epidemic has taken a drastic toll on people’s lives. Aromatherapy is just one of many alternative and complementary therapies for pain that could replace or reduce at least some of the use of these more harmful and habit-forming medications.

Unfortunately, false and dubious claims abound about the alleged powers and benefits of aromatherapy and essential oils, creating a significant stigma around their use in clinical settings. However, as more studies are conducted demonstrating which oils are effective for which treatments and how to safely use them,  overcoming this stigma could mean these all-natural, non-toxic therapies could decrease prescription drug dependency and use, not just for pain but for many other symptoms as well. 

Ascents® Clinical Aromatherapy

Lavender and orange are two of the primary essential oils that have demonstrated efficacy in pain reduction in clinical trials, and they are both present in the Ascents Calm No. 34 formula alongside patchouli, juniper berry, and ylang ylang. The Ascents Calm blend was specifically used in trials conducted at the Nebraska Children’s Hospital in a palliative care setting, in which it significantly reduced pain as well as anxiety

Ascents Calm No. 34 Clinical Aromatherapy Inhaler for Anxiety    Ascents Calm No. 34 Clinical Aromatherapy Gel for AnxietyAscents Calm No. 34 Essential Oil for AnxietyAscents Calm No. 34 Clinical Aromatherapy Patch for Anxiety

The Ascents Calm No. 34 blend is available in the form of personal inhalers, MRI-safe wearable patches, whole-room diffusers, and bottled oils. If you would like to try Ascents Calm or any of the other Ascents aromatherapy solutions, please fill out our Sample Request Form or call us at 800-671-1890.

Ascents Clinical Aromatherapy - Recommended by Doctors, Used by Hospitals®




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